DAVID L. PEARLE, M.D. Professor Director, Coronary Care Unit Pasquerilla Healthcare Center (PHC), 5th Floor Georgetown University Hospital Washington, DC 20007 (202) 444-8833 Office / (202) 444-1839 FAX pearled@gunet.georgetown.edu
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Publications

Gillis, R.A., D.L., Pearle, and T. Hokeman.  Failure of beta adrenergic receptor blockage to prevent arrhythmias induced by cardiac sympathetic nerve stimulation.

Science 185:70, 1974.

Pearle, D.L., and R.A. Gillis.  Effects of digitalis on the response of the ventricular pacemaker to sympathetic neural stimulation and to isoproterenol.

American Journal of Cardiology 34:704, 1974.

Gillis, R.A., D.L., Pearle, and B. Levitt.  Digitalis: A neuro-excitatory drug.  Circulation 52:379, 1975. 

Corr, P.B., D.L., Pearle, and R.A. Gillis.  Coronary occlusion site as a determinant of the cardiac rhythm effects of atropine and vagotomy.  

American Heart Journal 92:741, Dec. 1976.

Corr, P.B., D.L., Pearle, J.R. Hinton, W.C. Roberts, and R.A. Gillis.  Site of myocardial infarction-a determinant of the cardiovascular changes induced in the cat by coronary occlusion. Circulation Research 39:840, Dec. 1976.

Gillis, R.A., P.B. Corr, D.G. Pace, D.E. Evans, J. A. DiMicco, and D.L., Pearle.  Role of the nervous system in experimentally induced arrhythmias.  Cardiology 61:37, 1976.

DiMicco, J.A., R. Prestel, D.L., Pearle, and R.A. Gillis.  Mechanism of cardiovascular changes produced in cats by activation of the central nervous system with picrotoxin. Circulation Research 41:446, Oct. 1977.

Pearle, D.L., D.J. Williford, and R.A. Gillis.  Superiority of protocol versus propranolol in protection against ventricular fibrillation induced by coronary occlusion.  American Journal of Cardiology 42:960, 1978.

Pearle, D.L. Clinical experience with nifedipine for coronary artery spasm.  Medical Times 107:12, Dec. 1979.

Chizner, M.D., D.L., Pearle, and A.C. deLeon, Jr. Natural history of aortic stenosis in adults.  American Heart Journal 99:419-424, April, 1980.

Segal, S.A., D.L., Pearle, and R.A. Gillis.  Coronary spasm produced by picrotoxin in cats.  European Journal of Pharmacology 76: 447-451, 1981.

Pearle, D.L., J. Dias Souza, and R.A. Gillis.  Comparative vagolytic effects of procainamide and n-acetylprocainamide in the dog.

Journal of Cardiovascular Pharmacology, 5:450-453, 1983.

Pearle, D.L. Clinical experience with nifedipine for coronary artery spasm.

Resident & Staff Physician 26:4, 1979.

Muller, J.E., Z.G. Turi, D.L., Pearle, J.F. Schneider, D.H. Serfas, J. Morrison,

P.H. Stone, R.E. Ruide, B. Rosner, B.E. Sobel, C. Tate, E. Scheiner, R. Roberts,

C.H. Hennekens, and E. Braunwald.  Nifedipine and conventional therapy for unstable angina pectoris: A randomized double blind comparison.

Circulation 69:728-739, 1984.

Muller, J.E., J. Morrison, P.H. Stone, R.E. Rude, B. Rosner, R. Roberts,

D.L., Pearle, Z.G. Turi, J.F. Schneider, D.H. Serfas, C. Tate, E. Scheiner, , B.E. Sobel, C.H. Hennekens, and E. Braunwald.  Nifedipine therapy for patients with threatened and acute myocardial infarction: A randomized, double blind, placebo-controlled comparison.  Circulation 69:740-747, 1984.

Satler, L.F., S. Levine, A.A. Del Negro, D.L., Pearle, K.M. Kent, and C.E. Rackley.  Non-surgical coronary reperfusion in evolving myocardial infarction. 

Advances in Internal Medicine 30:231-242, 1984.

Satler, L.F., D.L., Pearle, S. Levine, C.E. Green, A.A. Del Negro, and C.E. Rackley.  Aortic dissection masquerading as acute myocardial infarction: Implication for thrombolytic therapy without cardiac catherization. 

American Journal of Cardiology 54:1134-1135, Nov 19984.

Pearle, D.L. Nifedipine in acute myocardial infarction.

American Journal of Cardiology 54:21 E. 1984.

Pearle, D.L.  Ischemia Heart Disease: Clinical update.  Monograph.  Home Study Assessment.  American Academy of Family Physicians 66, 1984.

Satler, L.F., D.L., Pearle, S. Levine, C.E. Green, A.A. Del Negro, K.M. Kent, and C.E. Rackley.  Changing concepts and treatment of unstable myocardial ischemia.  Primary Cardiology 10:88-94, 1984.

Gillis, R.A., B.I. Lee, and D.L., Pearle.  Practical pharmacology of anti-ischemic agents.  Consultant, 25-27, 68-92, April 1985.

Satler, L.F., C.E. Rackley, D.L., Pearle, R.D. Fletcher, and A.A. Del Negro.  Total inhibition of a physiologic pacing system due to antipacemaker-mediated tachycardiac mode.  PACE 8:806-810, 1985.

Satler, L.F., K.M. Kent, C.E. Green, D.L., Pearle, R.S. Pallas, A.A. Del Negro, and C.E. Rackley.  Thrombolysis in acute myocardial infarction.  In Advances in Critical Care Cardiology.  Philadelphia: F.A. Davis Company, 1986:39-52.

Rackley, C.E., L.F. Satler, D.L., Pearle, A.A. Del Negro, R.S. Pallas, and K.M. Kent.  The use of hemodynamic measurements for the management of acute myocardial infarction.  .  In Advances in Critical Care Cardiology.  Philadelphia: F.A. Davis Company, 1986:3-15.

Satler, L.F., C.E. Rackley, C.E. Green, R.S. Pallas, D.L., Pearle, A.A. Del Negro, and K.M. Kent.  Ischemia during angioplasty after streptokinase: A marker of myocardial salvage.  American Journal of Cardiology 56:749-752, 1985.

Krucoff, M.W., C.E. Green, L.F. Satler, F.C. Miller, R.S. Pallas, K.M. Kent,

A.A. Del Negro, D.L., Pearle, R.D. Fletcher, and C.E. Rackley.  Noninvasive detection of coronary artery patency using continuos ST segment monitoring. American Journal of Cardiology 57:916-922, 1986.

Satler, L.F., K.M. Kent, L.M. Fox, C.E. Green, W.J. Rogers, R.S. Pallas,

A.A. Del Negro, D.L., Pearle, and C.E. Rackley.  The assessment of contractile reserve after thrombolytic therapy for acute myocardial infarction. 

American Heart Journal 111:821-825, 1986.

Rackley, C.E., L.F. Satler, M.W. Krucoff, R.S. Pallas, D.L., Pearle, A.A. Del Negro,

and K.M. Kent.  Future directions for the diagnosis and treatment of acute myocardial infarction.  In: R.H. Cox, ed. Acute Myocardial Infarction.  New York: Praeger Publisher, Inc. in press.

Pearle, D.L. and C.E. Rackley.  Beta-blockers and calcium channel blocking agents in acute myocardial infarction.  In Advances in Critical Care Cardiology.  Philadelphia: F.A. Davis Company, 1986:29-38.

Katz, N.M., T.E. Kubanick, S.W. Ahmed, C.E. Green, D.L., Pearle, L.F. Satler,

C.E. Rackley, and R.B. Wallace.  Determinants of cardiac failure after coronary  bypass surgery within 30 days of acute myocardial infarction.

Satler, L.F., C.E. Green, K.M. Kent, R.S. Pallas, D.L., Pearle, and C.E. Rackley.

Metabolic support during coronary reperfusion.

American Heart Journal 114:54-58, 1987.

Satler, L.F., R.S. Pallas, O.B. Bond, C.E. Green, D.L., Pearle, G.L. Schaer,

K.M. Kent, and C.E. Rackley.  Assessment of the residual coronary arterial stenosis after thrombolytic therapy during acute myocardial infarction.

American Journal of Cardiology 59:1231-1233, 1987.

Satler, L.F., C.E. Green, N.M. McNamara, J.P. Lavelle, R.S. Pallas, D.L., Pearle,

K.M. Kent, and C.E. Rackley.  Late angiographic follow-up after successful thrombolysis and angioplasty.  American Journal of Cardiology 60:210-213, 1987.

Bowman, M.A., and D.L., Pearle.  Changes in drug prescribing patterns related to commercial company funding of continuing medical education.

Journal of Continuing Education Health Professional 8:13-20, 1988.

Pearle, D.L.,  Calcium antagonist in acute myocardial infarction.

American Journal of Cardiology 61:22B-25B, 1988.

Satler, L.F., D.L., Pearle, and C.E. Rackley.  Reduction in coronary heart disease: Anatomical considerations.  Clinical Cardiology 12:422-426, 1989.

Katz, N., P. Pierce, R. Anzeck, M. Visner, H. Canter, M. Forgh, D.L., Pearle,

C.M. Tracy, and A. Rahman.  Liposomal amphotericin B for treatment of pulmonary aspergillosis in a heart transplant patient. 

The Journal of Heart Transplantation, 9:14-17, Jan/Feb, 1990.

Pearle, D.L., Pharmacological management of ischemic heart disease with

B-blockers and calcium channel blockers.

American Heart Journal 120:739-742, September, 1990.

Packer, M., Narahara K.A., Elkayam U., Sullivan J.M., D.L., Pearle, Massie, B.M., and Creager, M.A.  Double blind, placebo-controlled study of the efficacy of flosequinan in patients with chronic heart failure. 

Journal American College of Cardiology, 22(1):65-72, July, 1993.

Coughlin, S.S., D.L., Pearle, K.L. Baughman, A. Wasserman, and M.C. Tefft

Diabetes mellitus and the risk of idiopathic dilated cardiomyopathy.  Annals of Epidemiology, 4:45-52, 1994.

Pearle, D.L. and DiBianco, R. Clinical Approach to Heart Failure in Classic Teachings in Teachings in Clinical Cardiology, Laennec Publishing, 1996.

Antman EM., Anbe DT;  Armstrong PW; Bates ER; Green LA; Hand M; Hochman JS; Krumholz HM; Kushner FG; Lamas GA; Mullany CJ; Ornato JP; Pearle DL; Sloan MA; Smith SC Jr; ACC/AHA Guidelines for the Management of Patients With  ST- Elevation Myocardial infarction-Executive Summary. J AM Coll Cardiol 2004;44: 671-719.

Antman EM; Anbe DT; Armstrong PW; Bates ER; Green LA; Hand M; Hochman JS; Krumholz HM; Kushner FG; Lamas GA; Mullany CJ; Ornato JP; Pearle DL; Sloan MA; Smith SC JR; ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction Executive Summary.  Circulation. 2004;110:588-636