Definition:
Acne is a skin condition characterized by whiteheads, blackheads, and inflamed red pimples or "zits."
Alternative Names: Acne vulgaris; Comedones; Cystic acne; Pimples; Zits

Causes, incidence, and risk factors:
The condition occurs when tiny holes on the surface of the skin, called pores, become clogged. Each pore is an opening to a canal called a follicle, which contains a hair and an oil gland. Normally, the oil glands help keep the skin lubricated and help remove old skin cells. When glands produce too much oil, the pores can become blocked, accumulating dirt, debris, and bacteria. The blockage is called a plug or comedone.

The top of the plug may be white (whitehead ) or dark (blackhead ). If it ruptures, the material inside, including oil and bacteria, can spread to the surrounding area and cause an inflammatory reaction. If the inflammation is deep in your skin, the pimples may enlarge to form firm, painful cysts.

Acne commonly appears on the face and shoulders, but may also occur on the trunk, arms, legs, and buttocks.

Acne is most common in teenagers, but it can happen at an age, even as an infant. Three out of four teenagers have acne to some extent, probably caused by hormonal changes that stimulate oil production. It may persist into a person's 30's and 40's.

Acne tends to run in families and can be triggered by:

Hormonal changes related to menstrual periods, pregnancy, birth control pills, or stress
Greasy or oily cosmetic and hair products
Certain drugs (such as steroids, testosterone, estrogen, and phenytoin)
High levels of humidity and sweating
Despite the popular belief that chocolate, nuts, and other foods cause acne, this does not seem to be true.

Symptoms:

• whiteheads
• blackheads
• pustules
• cysts
• redness around the skin eruptions
• inflammation around the skin eruptions
• crusting of skin eruptions
• scarring of the skin

Signs and tests:
Your doctor can diagnose acne based on the appearance of the skin. Testing is usually not required.

Treatment - Take the following self-care steps to lessen the effects of acne:

1. Clean your skin gently with a mild, non-drying soap (like Dove, Neutrogena, or Basics.) Remove all dirt or make-up. Wash once or twice a day, including after exercising. However, avoid excessive or repeated skin washing.
2. Shampoo your hair daily, especially if it's oily. Comb or pull your hair back to keep the hair out of your face. Avoid tight headbands.
3. Try not to squeeze, scratch, pick, or rub the pimples. Although it might be tempting to do this, it can lead to scarring and skin infections.
4. Avoid touching your face with your hands or fingers.
5. Avoid greasy cosmetics or creams. Look for water-based or "non-comedogenic" formulas. Take make-up off at night.
6. If these steps do not clear up the blemishes to an acceptable level, try over-the-counter acne medications. These creams and lotions are applied directly to the skin. They may contain benzoyl peroxide, sulfur, resorcinol, or salicylic acid. They work by killing bacteria, drying up the oil, and causing your skin to peel.

If the pimples are still a problem, a dermatologist can prescribe stronger medications and discuss other options with you.

Prescription medicines include:

• Oral antibiotics (such as minocycline, doxycycline, and tetracycline).
• Topical antibiotics (applied to the skin), such as clindamycin or erythromycin.
• Synthetic vitamin A derivatives, called retinoids, for severe acne. These include retinoic acid cream or gel (Retin-A) and isotretinoin pills (Accutane). Pregnant women and sexually active adolescent females should NOT take Accutane, as it causes severe birth defects.
• Birth control pills can sometimes help clear up acne. (In some cases, though, they may make it worse.)
  Prescription formulas of benzoyl peroxide, sulfur, resorcinol, salicylic acid.
• Your doctor may also suggest chemical skin peeling, removal of scars by dermabrasion, or removal or drainage of cysts.
• A small amount of sun exposure may improve acne. However, excessive exposure to sunlight or ultraviolet rays is not recommended because it increases the risk of skin cancer.

Expectations (prognosis):
Acne usually subsides after adolescence, but may last into middle age. The condition generally responds well to treatment after a few weeks, but may flare up from time to time. Scarring may occur if severe acne is not treated. Some people, especially teenagers, can become significantly depressed if acne is not treated.

Complications - Possible complications include:

• cysts
• permanent facial scars
• changes in skin color
• damage to self-esteem, confidence, personality, and social life
• side effects of Accutane (including liver damage and birth defects in an unborn baby)
• side effects of other medications

Calling your health care provider - Call your doctor or a dermatologist if:

• Self-care measures and over-the-counter medicine have not helped after several months.
• Your acne is severe (for example, you have lots of redness around the pimples or you have cysts) or getting worse.
• You develop scars as the your acne clears up.
• For infant acne, call your pediatrician if it does not clear up on its own in 3 months.

Hair follicle sebaceous gland:



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References:
American Academy of Dermatology. AcneNet page. Available at: http://www.skincarephysicians.com/acnenet/acne.html. Accessed March 23, 2005.

Habif TP. Acne, Rosacea, and Related Disorders. In: Clinical Dermatology. 4th ed.Mosby, Inc., 2004; 162-194.