Georgetown University - Department of Medicine

Comparison of thyroid hormone levels found with normal thyroid functioning to levels achieved during thyroid hormone replacement after thyroidectomy
This study is recruiting patients with normal thyroid function who will require surgery to remove their thyroid gland. This study examines the levels of thyroid hormones in the blood of euthyroid patients before they undergo their thyroid surgery. These levels are then compared with thyroid hormone levels when patients are on a stable replacement dose of thyroid hormone.
Identification of leukocyte genes that are regulated by thyroid hormone
This study is recruiting patients with either overactivity or underactivity of the thyroid before they begin their treatment. This study looks at the expression of genes in the blood of patients while they are either hypothyroid or hyperthyroid. The expression of these genes is then re-examined when the patients have been treated to achieve normal thyroid function.
A Pilot Study of the Effect of Time of Levothyroxine Administration on Serum TSH
This study is recruiting patients being treated with thyroid hormone for hypothyroidism. During the study the timing of the patient’s dose of thyroid hormone is changed for a short period of time to see if this change effects the patients thyroid status as assessed by routine thyroid blood tests.

2. Influence of different treatments on the outcome of thyroid cancer
Georgetown University is a participant in the National Thyroid Cancer Treatment Cooperative Study Group. This multi-institution registry prospectively follows a large cohort of thyroid cancer patients in order to study the impact of initial and adjuvant therapies on progression and survival of patients with thyroid cancer. Patients within the registry receive the usual care provided by the physician who is treating their thyroid cancer.

3. Phase II Study of Decitabine in Patients with Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Radioiodine
This study is recruiting patients whose thyroid cancer has not been adequately treated by radioactive iodine. This study is sponsored by the National Cancer Institute and involves determining whether decitabine will restore the responsiveness of thyroid cancer that is currently unresponsive to radioactive iodine. For information see the Lombardi Comprehensive cancer Center Clinical trials site.
(http://lombardi.georgetown.edu/clinicalprotocols/index.cfm)

4.Phase II Study of Bortezomib in Metastatic Papillary Thyroid Carcinoma or Follicular Thyroid Carcinoma
This study is recruiting patients with metastatic thyroid cancer. The study is being sponsored by the National Cancer Institute. The impact of bortezomib on metastatic thyroid cancer refractory to more conventional therapy will be assessed in this trial. For information see the Lombardi Comprehensive cancer Center Clinical trials site.
(http://lombardi.georgetown.edu/clinicalprotocols/index.cfm)