Basic Research

The Laboratories of Christopher Wilcox, MD, PhD & William Welch, PhD

This research is supported by three RO-1 and one PO-1 (Program Project Grant) from the NIH Research centered on:

• Pathophysiology of renovascular hypertension.
• Role of nitric oxide and oxidative stress in the regulation of blood pressure and kidney function.
• Mechanisms of progressive loss of kidney funtion in models of chronic kidney disease.
• Roles of isoprostanes, adenosine and vasoconstrictor prostaglandins in tubuloglomerular, CKD and hypertension.
• Regulation of renal oxygenation.
• Studies of the isolated perfused renal afferent arterioles, mesenteric resistance vessels and cerebral microarterioles
• Renal myogenic and autoregulatory responses.
• Novel diuretic drugs.
• Novel antioxidant drugs.
• Role of microarteriolar cellular senesence in hypertension, aging and vascular dementia

The Laboratories of Christopher Wilcox, MD, PhD & Dan Wang, MD, PhD

• Human microvascular defects in aging and the menopause
• Human microvascular function in people living with HIV or patients with hypertension
• Microvascular defects in the placentas of women living with HIV

The Laboratories of Kathryn Sandberg, PhD

• Interaction of sex hormones with the renin angiotensin system.
• G protein-coupled receptors.
• Post-transcriptional regulation.