The Laboratories of Christopher Wilcox, MD, PhD & William Welch, PhD
This research is supported by three RO-1 and one PO-1 (Program Project Grant) from the NIH Research centered on:
- Pathophysiology of renovascular hypertension.
- Role of nitric oxide and oxidative stress in the regulation of blood pressure and kidney function.
- Mechanisms of progressive loss of kidney funtion in models of chronic kidney disease.
- Roles of isoprostanes, adenosine and vasoconstrictor prostaglandins in tubuloglomerular, CKD and hypertension.
- Regulation of renal oxygenation.
- Studies of the isolated perfused renal afferent arterioles, mesenteric resistance vessels and cerebral microarterioles
- Renal myogenic and autoregulatory responses.
- Novel diuretic drugs.
- Novel antioxidant drugs.
- Role of microarteriolar cellular senesence in hypertension, aging and vascular dementia
The Laboratories of Christopher Wilcox, MD, PhD & Dan Wang, MD, PhD
- Human microvascular defects in aging and the menopause
- Human microvascular function in people living with HIV or patients with hypertension
- Microvascular defects in the placentas of women living with HIV
The Laboratories of Kathryn Sandberg, PhD
- Interaction of sex hormones with the renin angiotensin system.
- G protein-coupled receptors.
- Post-transcriptional regulation.